General description

A cell permeable imidazoxanthine shown to decrease TGF-β stimulated reporter activity in a dose-dependent manner in HEK293 reporter cells, with an IC₅₀ of 4.1 µM without cell cytotoxicity. Inhibits TGF-β receptor I (TβRI) and TGF-β receptor II (TβRII) expression and its downstream Smad2 and Smad3 phosphorylation as well as JNK and ERK activity. In addition, it elicits TGF-β-induced fibroblast differentiation with attenuated expression of several fibrotic markers such as α-SMA and fibronectin, and suppresses collagen accumulation in CCD-18Lu human normal lung fibroblasts.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Park, S., et al. 2010. Biochem. Biophy. Res. Comm.399, 268.

Packaging

10 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)